Ontores/IL-6受体/5mg/ONP10765
商品编号：
ONP10765
品牌：
ontorespeptide
市场价：
¥760.00
美元价：
380.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
BIOLOGICAL INFORMATION
DescriptionA soluble form of the Interleukin-6 receptor (IL-6R) was initially identified in the urine of healthy adult humans, in culture supernatants from HTLV-I positive T cell lines and in the serum of HIV-seropositive blood donors. These soluble receptors (Interleukin-6 receptor) may develop as a result of alternate splicing of the mRNA or as a result of proteolytic cleavage and release of the membrane-bound form of the receptor. Recombinant, Human IL-6 Soluble Receptor was produced by cloning the cDNA of the IL-6R and introducing a stop codon into the cDNA sequence immediately preceding the transmembrane domain. This was followed by infection of Sf 21 insect cells with recombinant baculovirus encoding the sequence for the truncated receptor. The IL-6 soluble receptor is 339 amino acid residues in length. IL-6 soluble receptor may serve to transport IL-6, protecting IL-6 from proteolysis. Alternatively, the IL-6 soluble receptor may act as an inhibitory agent to localize the activity of IL-6 or to bind IL-6 that is not bound to cell surface receptors. The bioactivity of IL-6 increases after binding to the soluble IL-6 receptor.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10765
CAS No.N/A
NameInterleukin (IL)-6 Receptor
Chemical NameInterleukin-(IL)-6-Receptor
Purity≥98%
SynonymsIL-6 RIL6R peptide
FormulaC51H85N13O21
Molecular Weight1216.3
One Letter CodeTSLPVQDSSSVP
Three Letter CodeTHR-SER-LEU-PRO-VAL-GLN-ASP-SER-SER-SER-VAL-PRO
SMILESN/A
InChI KeyN/A
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Karaduman M, et al. Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque. Clin. Exp. Immunol. Mar 2006; 143(3): 452-457.
2.Zhang PL, et al. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol. Cell. Neurosci. Mar 2006; 31(3): 387-398.
3.Maggio M, et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J. Clin. Endocrinol. Metab. Jan 2006; 91(1): 345-347.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
品牌介绍
cGMP肽合成服务肽在临床应用中的使用逐年增加。数十种肽已作为药物销售，数百种处于临床开发的不同阶段。肽由于具有分子量小，靶向选择性高，活性高，毒性低，易于渗透和吸收等突出特点而被用作药物。随着市场规模的不断扩大，越来越多的公司选择参与这一市场。凭借其能够进行商业化的良好生产规范（cGMP）制造的能力以及用于小型非GMP定制肽的能力，ONTORES可以满足从研究到商业化的药物肽开发各个阶段的需求。ONTORES是您值得信赖的高度复杂肽源。我们通过不断投资开发可提供最高质量肽段的专有化学产品，努力超越预期。ONTORES提供灵活的批量大小，从小规模到大规模生产，包括合成，纯化和冻干。
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