Ontores/Cortistatin 14，人，大鼠/0.5mg/ONP10134
商品编号：
ONP10134
品牌：
ontorespeptide
市场价：
¥1320.00
美元价：
660.00
产品分类：
旋转混合仪
公司分类：
Rotary_mixer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
BIOLOGICAL INFORMATION
DescriptionCortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin 14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin 14 was injected intracerebroventricularly after footshock avoidance training into each of a group of CD-1 mice. After one week, training was resumed to determine the effect of cortistatin 14 on retention. Cortistatin 14 was found to impair retention relative to the control group at doses of 0.5-5.0 micrograms.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10134
CAS No.186901-48-4
NameCortistatin 14, human, rat
Chemical NameCortistatin-14,-human,-rat
Purity≥98%
SynonymsCST-14
FormulaC81H113N19O19S2
Molecular Weight1721.01
One Letter CodePCKNFFWKTFSSCK
Three Letter CodePRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS
SMILESCC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
InChI KeyDDRPLNQJNRBRNY-WYYADCIBSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Aourz N, Portelli J, Coppens J, et al. Cortistatin-14 Mediates its Anticonvulsant Effects Via sst2 and sst3 but Not Ghrelin Receptors. CNS Neurosci Ther. 2014 Mar 31. [Epub ahead of print]. PMID: 24685142.
2.Markovics A, Szoke É, Sándor K, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. PMID: 21695504.
3.Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
品牌介绍
cGMP肽合成服务肽在临床应用中的使用逐年增加。数十种肽已作为药物销售，数百种处于临床开发的不同阶段。肽由于具有分子量小，靶向选择性高，活性高，毒性低，易于渗透和吸收等突出特点而被用作药物。随着市场规模的不断扩大，越来越多的公司选择参与这一市场。凭借其能够进行商业化的良好生产规范（cGMP）制造的能力以及用于小型非GMP定制肽的能力，ONTORES可以满足从研究到商业化的药物肽开发各个阶段的需求。ONTORES是您值得信赖的高度复杂肽源。我们通过不断投资开发可提供最高质量肽段的专有化学产品，努力超越预期。ONTORES提供灵活的批量大小，从小规模到大规模生产，包括合成，纯化和冻干。
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