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当前位置: 首页 > 产品中心 > Other_imaging > Ontores/c(RGDf(NMe)V)/100mg/ONP10928
商品详细Ontores/c(RGDf(NMe)V)/100mg/ONP10928
Ontores/c(RGDf(NMe)V)/100mg/ONP10928
Ontores/c(RGDf(NMe)V)/100mg/ONP10928
商品编号: ONP10928
品牌: ontorespeptide
市场价: ¥10160.00
美元价: 5080.00
产地: 美国(厂家直采)
公司:
产品分类: 其它成像系统
公司分类: Other_imaging
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
BIOLOGICAL INFORMATION
DescriptionPotent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10928
CAS No.188968-51-6
Namec(RGDf(NMe)V)
Chemical Namec(RGDf(NMe)V)
Purity≥98%
SynonymsCilengitide
FormulaC27H40N8O7
Molecular Weight588.67
One Letter Codec(RGDf(NMe)V)
Three Letter CodeCyclo(Arg-Gly-Asp-D-Phe-NMe-Val)
SMILESCC(C)C1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N
InChI KeyAMLYAMJWYAIXIA-VWNVYAMZSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Alghisi et al (2009) The integrin antagonist cilengitide activates αvβ3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One 4 e4449 PMID: 19212436
2.Monnier et al (2008) CYR61 and αvβ5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 68 7323 PMID: 18794119
3.Yamada, S.,Bu, X.-Y.,Khankaldyyan, V., et al. Effect of the angiogenesis inhibitor cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery 59(6), 1304-1312 (2006)
DOCUMENTATIONS
  • COA
  • Data sheet
  • MS
  • RP-HPLC
  • MSDS
  • Handling Instruction
PROMOTIONS & EVENTS
品牌介绍
cGMP肽合成服务肽在临床应用中的使用逐年增加。数十种肽已作为药物销售,数百种处于临床开发的不同阶段。肽由于具有分子量小,靶向选择性高,活性高,毒性低,易于渗透和吸收等突出特点而被用作药物。随着市场规模的不断扩大,越来越多的公司选择参与这一市场。凭借其能够进行商业化的良好生产规范(cGMP)制造的能力以及用于小型非GMP定制肽的能力,ONTORES可以满足从研究到商业化的药物肽开发各个阶段的需求。ONTORES是您值得信赖的高度复杂肽源。我们通过不断投资开发可提供最高质量肽段的专有化学产品,努力超越预期。ONTORES提供灵活的批量大小,从小规模到大规模生产,包括合成,纯化和冻干。